Not having Toth, Cantwell, Wharton or Tronstad will make this game significantly harder.
We have no other first team centre backs available, so should Wharton not make it, you're either reverting to a back 4, or dropping someone like Ribeiro into the back 3. Either way, it's risky.
Centre mid also presents a problem, as we either have to start with TGH and Forshaw (seems the most likely), or risk starting Montgomery or Taveres (who's been poor)
Pears is a huge problem regardless and Eustace will know how to unsettle him.